2. Signaling Pathways
  3. Antibody-drug Conjugate/ADC Related
  4. ADC Linker

Antibody-drug conjugates linker

ADC Linker

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Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.

The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.

The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.

ADC Linker Isoform Specific Products:

ADC Linker Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-173633
    BrAc-Val-Ala
    BrAc-Val-Ala is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as ABBV-969.
    BrAc-Val-Ala
  • HY-172290
    Benzyl N1-[PEG1-NHS]-N6-(t-Boc)-L-lysinate
    Benzyl N1-[PEG1-NHS] -N6-(t-Boc)-L-lysinate is a multifunctional ADC linker consisting of a terminal benzyl group, one PEG unit, an NHS ester, and a t-Boc-protected L-lysine, often used for bioconjugation and chemical modifications in R&D.
    Benzyl N1-[PEG1-NHS]-N6-(t-Boc)-L-lysinate
  • HY-W105531
    Fmoc-Ala-Ala-Pro-OH
    Fmoc-Ala-Ala-Pro-OH is a F-moc protected tripeptide linker which may be employed in the creation of antibody drug conjugates (ADCs).
    Fmoc-Ala-Ala-Pro-OH
  • HY-151762
    (2R,4S)-Fmoc-D-Pro(4-N3)-OH
    (2R,4S)-Fmoc-D-Pro(4-N3)-OH is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    (2R,4S)-Fmoc-D-Pro(4-N3)-OH
  • HY-151828
    N3-Gly-Aeg(Fmoc)-OH
    N3-Gly-Aeg(Fmoc)-OH is a click chemistry reagent containing an azide group. PNA building-block that can be further modified using Click-chemistry. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    N3-Gly-Aeg(Fmoc)-OH
  • HY-151729
    N3-D-Dab(Boc)-OH
    N3-D-Dab(Boc)-OH is a click chemistry reagent containing an Azide. N3-D-Dab(Boc)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-D-Dab(Boc)-OH
  • HY-151694
    H-L-Orn(N3)-OH hydrochloride
    H-L-Orn(N3)-OH (hydrochloride) is a click chemistry reagent containing an azide group. H-L-Orn(N3)-OH (hydrochloride) can be used for the research of various biochemical. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    H-L-Orn(N3)-OH hydrochloride
  • HY-151703A
    Boc-D-Lys(N3)-OH (CHA)
    Boc-D-Lys(N3)-OH CHA is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Boc-D-Lys(N3)-OH (CHA)
  • HY-W591402
    3,4-Dibromo-Mal-PEG4-Acid
    3,4-Dibromo-Mal-PEG4-acid is a site specific ADC linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.
    3,4-Dibromo-Mal-PEG4-Acid
  • HY-151850
    (2S,4R)-Fmoc-L-Pro(4-N3)-OH
    (2S,4R)-Fmoc-L-Pro(4-N3)-OH is a click chemistry reagent containing an azide. (2S,4R)-Fmoc-L-Pro(4-N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    (2S,4R)-Fmoc-L-Pro(4-N3)-OH
  • HY-W419403
    Boc-D-Aza-OH (CHA)
    Boc-D-Aza-OH (CHA) is a click chemistry reagent. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Boc-D-Aza-OH (CHA)
  • HY-151865A
    (2S,4S)-H-L-Pro(4-N3)-OH hydrochloride
    (2S,4S)-H-L-Pro(4-N3)-OH (hydrochloride) is a click chemistry reagent. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    (2S,4S)-H-L-Pro(4-N3)-OH hydrochloride
  • HY-151740
    4-Pentynoyl-Val-Ala-PAB-PNP
    4-Pentynoyl-Val-Ala-PAB-PNP is a cleavable ADC linker, that has been used to synthesis cryptophycin conjugates. 4-Pentynoyl-Val-Ala-PAB-PNP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    4-Pentynoyl-Val-Ala-PAB-PNP
  • HY-W352966
    Mal-PEG2-CH2COOH
    Mal-PEG2-CH2COOH is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Mal-PEG2-CH2COOH
  • HY-W540023
    endo-BCN-Fmoc-L-Lysine
    Endo-BCN-Fmoc-L-Lysine is a linker containing the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.
    endo-BCN-Fmoc-L-Lysine
  • HY-151732
    Z-D-Dbu(N3)-OH
    Z-D-Dbu(N3)-OH is a click chemistry reagent containing an azide group. Z-D-Dbu(N3)-OH can be used for the research of various biochemical. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Z-D-Dbu(N3)-OH
  • HY-151695
    Fmoc-L-Lys(Pryoc)-OH
    Fmoc-L-Lys(Pryoc)-OH (N2-Fmoc-N6-[(propargyloxy)carbonyl]-L-lysine) is a click chemistry reagent containing an azide group.
    Fmoc-L-Lys(Pryoc)-OH
  • HY-151794
    DACN(Ms) hydrochloride
    DACN(Ms) (hydrochloride) (compound 1ba) is a click chemistry reagent containing cyclononyne alkyne. DCN(Ms) (hydrochloride) has high thermal stability, chemical stability, water solubility, and high reactivity for cycloaddition reactions.
    DACN(Ms) hydrochloride
  • HY-151782
    H-(Gly)3-Lys(N3)-OH
    The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction. Polyglycine fragments containing up to 7 glycines are reported to bind to surfaces and have potential application in nanotechnology constructs: constructs of Gly7-NHCH2-fragment containing peptides bind on mica surface in aqueous solution. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    H-(Gly)3-Lys(N3)-OH
  • HY-151691
    Trisulfo-Cy3 Methyltetrazine
    Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures.
    Trisulfo-Cy3 Methyltetrazine
ADC Linker Isoform Comparison

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